The nails are present at the end of each fingertip on the dorsal surface. The main function of nails is protection and it also helps for a firm grip for holding articles. It consists of a strong relatively flexible keratinous nail plate originating from the nail matrix. Under the nail plate, there is a soft tissue called a nail bed. Between the skin and nail plate, there is a nail fold or cuticle. A normal healthy nail is slightly pink and the surface is convex from side to side. Fingernails grow 1 cm in three months and toenails take 24 months for the same.

Importance of nails in disease diagnosis:

The color, appearance, shape, and nature of the nails give some information about the general health and hygiene of a person. Nails are examined as a routine by all doctors to get some clues about underlying diseases. Just looking at nails we can make out the hygiene of a person. The abnormal nail may be congenital or due to some diseases. The cause for changes in the nail extends from simple reasons to life-threatening diseases. Hence the examination by a doctor is essential for diagnosis. Some abnormal findings with probable causes are discussed here for general awareness.

1) Hygiene:-

We can make out an unhygienic nail very easily. Deposition of dirt under the distal end of the nail plate can make a chance for ingestion of pathogens while eating. If nail cutting is not done properly it can result in worm troubles in children. When the worms crawl in the anal orifice children will scratch which lodges the ova of worms under the nails and will be taken in while eating. Prominent nails can also complicate a skin disease by habitual scratching. Sharp nails in small kids cause small wounds when they do feet kicking or hand waving.

2) Colour of the nails:-

a) Nails become pale in anemia.

b) Opaque white discoloration (leuconychia) is seen in chronic renal failure and nephrotic syndrome.

c) Whitening is also seen in hypoalbuminemia as in cirrhosis and kidney disorders. 


d) Drugs like sulpha group, anti malarial and antibiotics ect can produce discoloration in the nails.


e) Fungal infection causes black discoloration.

f) In pseudomonas infection nails become black or green.

g) Nail bed infarction occurs in vasculitis, especially in SLE and polyarteritis.

h) Red dots are seen in nails due to splinter hemorrhages in subacute bacterial endocarditis, rheumatoid arthritis, trauma, collagen vascular diseases. 

i) Blunt injury produces hemorrhage and causes blue/black discoloration.


j) Nails become brown in kidney diseases and decreased adrenal activity.

k) In wilsons disease blue color in semicircle appears in the nail.

l) When the blood supply decreases nail become yellow. In jaundice and psoriasis also nail becomes yellowish.

m) In yellow nail syndrome all nails become yellowish with pleural effusion.

3) Shape of nails:-

a) Clubbing: Here tissues at the base of nails are thickened and the angle between the nail base and the skin is obliterated. The nail becomes more convex and the fingertip becomes bulbous and looks like an end of a drumstick. When the condition becomes worse the nail looks like a parrot beak.

Causes of clubbing:-

Congenital Injuries

Severe chronic cyanosis

Lung diseases like empyema, bronchiectasis, carcinoma of bronchus, and pulmonary tuberculosis. 

Abdominal diseases like Crohn's disease, polyposis of the colon, ulcerative colitis, liver cirrhosis ect...

Heart diseases like Fallot's tetralogy, subacute bacterial endocarditis,s, and ect.

b) Koilonychia:-

Here the nails become concave like a spoon. This condition is seen in iron deficiency anemia. In this condition, the nails become thin, soft, and brittle. The normal convexity will be replaced by concavity.

c) Longitudinal ridging is seen in Raynaud's disease.

d) Cuticle becomes ragged in dermatomyositis.

e) Nail fold telangiectasia is a sign in dermatomyositis, systemic sclerosis, and SLE.

4) Structure and consistency:-

a) Fungal infection of nails causes discoloration, deformity, hypertrophy, and abnormal brittleness.

b) Thimble pitting of nails is characteristic of psoriasis, acute eczema, and alopecia Areata.


c) The inflammation of the cuticle or nail fold is called paronychia.

d) Onycholysis is the separation of nail beds seen in psoriasis, infection, and after taking tetracyclines.

e) Destruction of the nail is seen in lichen planus, epidermolysis bullosa.

f) Missing nail is seen in nail-patella syndrome. It is a hereditary disease.

g) Nails become brittle in Raynaud's disease and gangrene.

h) Falling of nails is seen in fungal infection, psoriasis, and thyroid diseases.


5) Growth:-

Reduction in blood supply affects the growth of nails. Nail growth is also affected by insevere illnesses. when the disease disappears the growth starts again resulting in the formation of transverse ridges. These lines are called Beau's lines and are helpful to date the onset of illness.

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